Broadly neutralizing antibodies (bNAbs) are thought to be the future for treating and preventing HIV infections. A bNAb recently characterized by Caltech researchers can neutralize HIV in different states—increasing the antibody's promise as a therapeutic.
Finding an anti-AIDS vaccine remains an elusive goal—partly because the HIV virus quickly mutates to evade the vaccine's antibodies. In a Watson Lecture on April 1, Caltech's Pamela J. Bjorkman will describe ways to neutralize that mutational advantage.
Researchers around the country are adopting a technique developed in the Caltech lab of Nobel Laureate David Baltimore to try to guard against infection. The method, called VIP, was originally designed to trigger an immune response to HIV.
"The method that we developed has now been validated in the most natural possible setting in a mouse," says David Baltimore, president emeritus and the Robert Andrews Millikan Professor of Biology at Caltech.
Researchers at Caltech are the first to have utilized high-resolution electron microscopy to look at HIV infection within the actual tissue of an infected organism, providing perhaps the most detailed characterization yet of HIV infection in the gut.