Brain and Neural Disorders
Human brain imaging and neuropsychiatric disease; neural prosthetics; deep brain stimulation; interactions of brain and immune system; mouse models of neurological disease.
Molecular Medicine and Diagnostics
Engineering immunity, cancer vaccines, AIDS vaccine, novel anti-cancer therapeutics, Parkinson's disease, nicotine addiction, microbiome perturbations in disease, molecular basis of autism, programmable chemo therapies, conditional chemo therapies, nano particle drug delivery.
Stem Cell Biology
Laboratories working in the area of stem cell biology are focusing on cell lineage decisions in the early embryo and what drives cells from a pluripotent to more restricted state, eventually leading to differentiation into defined cell types. To achieve these goals, we utilize a variety of approaches including high resolution live imaging, lineage tracing, genomic and epigenomic profiling on the whole embryo and single cell level coupled with perturbation approaches.
Virology and Immunology
The immune system is our defense against pathogenic microorganisms. It involves an innate branch that recognizes generic aspects of pathogens and an adaptive branch that recognizes specific molecules on pathogens. Caltech laboratories are using structural biology, molecular biology, and mouse genetics to study how the immune system develops, how the immune system interacts with microbes that naturally reside in our bodies and are not pathogens, and how signals are transduced in both the innate and adaptive branches of the immune system. In addition, there is a strong translational medicine effort, with a focus on pathologies of the immune system including cancer, engineering antibodies to produce more potent vaccines, and engineering immune cells to attack cancer.