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Developmental Biology and Stem Cell Biology

Laboratories working in the area of stem cell biology are focusing on cell lineage decisions in the early embryo and what drives cells from a pluripotent to more restricted state, eventually leading to differentiation into defined cell types. To achieve these goals, we utilize a variety of approaches including high resolution live imaging, lineage tracing, genomic and epigenomic profiling on the whole embryo and single cell level coupled with perturbation approaches. (Bronner, Elowitz, Guttman, Rothenberg, Stathopoulos, Zernicka-Goetz)

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Mouse - First Pluripotent Cells

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Mouse Embryos at the Blastocyst Stage

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Mouse Embryos at the Blastocyst Stage

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Mouse Embryo After Implantation

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Embryonic Stem Cells Self-organising into an Embryo

Explanted cranial neural crest cells electroporated with H2B-RFP (red, nuclear) and GPI-GFP (membrane, cyan)

Explanted Cranial Neural Crest Cells Electroporated with H2B-RFP (red, nuclear) and GPI-GFP (membrane, cyan)

A transverse section through a chick embryos highlighting neural crest cells in red

A Transverse Section Through a Chick Embryo Highlighting Neural Crest Cells in Red