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04/21/2011

Learning to Tolerate Our Microbial Self

Kathy Svitil

The human gut is filled with 100 trillion symbiotic bacteria which we blissfully live with, although they look very similar to infectious bacteria we react against. What decides whether we ignore—or fight? In the case of a common "friendly" gut bacterium, Bacteroides fragilis, Caltech researchers have discovered the surprising answer: The decision is not made by us, but by the bacteria, who co-opt cells of the immune system for our benefit—and theirs.

04/14/2011

Caltech Biologist Recognized for Cellular Noise Research

Katie Neith

Nearly ten years ago, Michael Elowitz, Caltech Bren Scholar and professor of biology, bioengineering, and applied physics, first amplified the idea that stochasticity—or noise—plays an important role in the process of gene expression. For his pioneering work, Elowitz has been named the winner of the 2011 Human Frontier Science Program Nakasone Award. 

 

03/07/2011

Pamela Bjorkman Named Among Most Powerful Moms

Lori Oliwenstein

When Working Mother magazine recently compiled its list of the Most Powerful Moms in STEM (Science, Technology, Engineering, and Math), it included Caltech's Pamela Bjorkman—a pioneer in the study of cell-surface recognition in the immune system, and a mother of two—among its 10 honorees. 

02/10/2011

Caltech-Led Team Pinpoints Aggression Neurons in the Brain

Lori Oliwenstein

Where does violence live in the brain? And where, precisely, does it lay down its biological roots? With the help of a new genetic tool that uses light to turn nerve cells on and off, a team led by researchers at the California Institute of Technology (Caltech) has tracked down the specific location of the neurons that elicit attack behaviors in mice, and defined the relationship of those cells to the brain circuits that play a key role in mating behaviors.

02/02/2011

Neurobiologists Find that Weak Electrical Fields in the Brain Help Neurons Fire Together

Kathy Svitil

The brain—awake and sleeping—is awash in electrical activity, and not just from the individual pings of single neurons communicating with each other. In fact, the brain is enveloped in countless overlapping electric fields, generated by the neural circuits of scores of communicating neurons. The fields were once thought to be a 'bug' of sorts, occurring during neural communication. New work, however, suggests that the fields do much more—and that they may, in fact, represent an additional form of neural communication.

01/31/2011

Why Do We Sleep?

Marcus Woo

While we can more or less abstain from some basic biological urges—for food, drink, and sex—we can’t do the same for sleep. At some point, no matter how much espresso we drink, we just crash. And every animal that’s been studied, from the fruit fly to the frog, also exhibits some sort of sleep-like behavior. But why do we—and the rest of the animal kingdom—sleep in the first place?

11/18/2010

David Anderson, Christof Koch Named Allen Distinguished Investigators

Lori Oliwenstein

Two Caltech researchers—David Anderson and Christof Koch—have been named by the Paul G. Allen Family Foundation among the inaugural group of Allen Distinguished Investigators. The foundation's new program aims to advance important research in neuroscience and cellular engineering.

11/10/2010

Caltech Scientists Describe the Delicate Balance in the Brain that Controls Fear

Lori Oliwenstein

A research team led by scientists at Caltech has taken an important step toward understanding the neural circuitry of fear. In a paper published in this week's issue of the journal Nature, they describe a microcircuit in the amygdala that controls, or "gates," the outflow of fear from that region of the brain.

10/27/2010

Controlling Individual Cortical Nerve Cells by Human Thought

Kathy Svitil

Caltech neuroscientist Christof Koch, postdoc Moran Cerf, and their colleagues have found that individuals can exert conscious control over single neurons in the brain—despite the neurons' location in a brain region previously thought inaccessible to conscious control—and manipulate the behavior of an image on a computer screen.

10/04/2010

Two Caltech Scientists Named Among 2010 NIH Director's New Innovator Awardees

Lori Oliwenstein

As part of a National Institutes of Health (NIH) initiative to stimulate highly innovative research and support promising new scientific investigators, two scientists from Caltech were named among the 2010 class of the NIH Director's New Innovator Award recipients.