Medical and Electrical Engineering Defense, Jiahong Li

Advances in bioelectronic technologies are enabling continuous health monitoring and closed-loop therapeutic intervention. However, a fundamental challenge remains: the mechanical and functional mismatch between rigid electronics and soft, dynamic biological tissues, leading to unstable interfaces and unreliable performance.

To bridge the gap between tissue and bioelectronics, I developed a multimodal bioelectronic system with biphasic elastomer–hydrogel platform designed to bridge this interface. By integrating mechanically compliant elastomers with adhesive hydrogels, this system enables stable, conformal contact with tissues while supporting multimodal sensing and stimulation. This system achieves reliable in vivo signal acquisition, stable adhesion, and integrated neuromodulation, demonstrating a path toward robust implantable bioelectronics.

In addition, scalable fabrication is essential for translating bioelectronics from lab-scale prototypes to real-world applications. Here, I develop printing-based methods that enable mask-free, large-area, multimaterial patterning with strong formulation flexibility, allowing new functions to be incorporated without redesigning the entire device.

Together, this work establishes a materials-to-systems approach for next-generation bioelectronics, advancing wearable and implantable platforms for continuous monitoring, adaptive therapy, and intelligent human–machine interfaces.