Professor of Biology; Executive Officer for Biology and Biological Engineering
Research Summary
Mechanisms of large non-coding RNA mediated regulation of gene expression and cell state
Profile
Over the past decade, it has become clear that mammalian genomes encode thousands of long non-coding RNAs (lncRNAs), many of which are now implicated in diverse biological processes. Our lab aims to understand the mechanisms by which lncRNAs act to control cellular functions. Specifically, we aim to understand how lncRNAs can regulate gene expression by coordinating regulatory proteins, localizing to genomic DNA targets, and shaping three-dimensional (3D) nuclear organization.
